Laminar Flow Activates Peroxisome Proliferator-Activated Receptor-γ in Vascular Endothelial Cells
نویسندگان
چکیده
منابع مشابه
Laminar flow activates peroxisome proliferator-activated receptor-gamma in vascular endothelial cells.
BACKGROUND Steady laminar flow is atheroprotective, in part because of its antiinflammatory effects on vascular endothelial cells (ECs). We studied the activation of peroxisome proliferator-activated receptor-gamma (PPARgamma) in ECs in response to laminar flow and the associated antiinflammatory effect. METHODS AND RESULTS Using flow channel with cultured ECs, we found that laminar flow acti...
متن کاملLaminar Flow Activates Peroxisome Proliferator–Activated Receptor- in Vascular Endothelial Cells
Background—Steady laminar flow is atheroprotective, in part because of its antiinflammatory effects on vascular endothelial cells (ECs). We studied the activation of peroxisome proliferator–activated receptor(PPAR ) in ECs in response to laminar flow and the associated antiinflammatory effect. Methods and Results—Using flow channel with cultured ECs, we found that laminar flow activated the PPA...
متن کاملRole of Peroxisome Proliferator-Activated Receptor-γ in Vascular Inflammation
Vascular inflammation plays a crucial role in atherosclerosis, and its regulation is important to prevent cerebrovascular and coronary artery disease. The inflammatory process in atherogenesis involves a variety of immune cells including monocytes/macrophages, lymphocytes, dendritic cells, and neutrophils, which all express peroxisome proliferator-activated receptor-γ (PPAR-γ). PPAR-γ is a nucl...
متن کاملPeroxisome proliferator-activated receptor-γ protects against vascular aging.
Vascular disease occurs commonly during aging. Carotid artery and cerebrovascular disease are major causes of stroke and contributors to dementia. Recent evidence suggests that peroxisome proliferator-activated receptor-γ (PPARγ) may play a protective role in the vasculature, but the potential importance of PPARγ in vascular aging is unknown. To examine the hypothesis that PPARγ normally protec...
متن کاملPeroxisome Proliferator-Activated Receptor γ Regulates the Expression of Lipid Phosphate Phosphohydrolase 1 in Human Vascular Endothelial Cells
Lipid phosphate phosphohydrolase 1 (LPP1), a membrane ectophosphohydrolase regulating the availability of bioactive lipid phosphates, plays important roles in cellular signaling and physiological processes such as angiogenesis and endothelial migration. However, the regulated expression of LPP1 remains largely unknown. Here, we aimed to examine a role of peroxisome proliferator-activated recept...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Circulation
سال: 2004
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.0000139850.08365.ec